When the differences in the immune cell subtypes between the benign oncocytoma and malignant RCC (clear cell, chromophobe, papillary) cases (n = 45) were analyzed, we found that the oncocytoma cases had a lower percentage of CD3+ (p = .0082 median 34% vs 64.5%) and CD4+ (p = .038 median 23.3% vs 36.4%) T cells. The gene discussed is CD4; the disease is oncocytic adenoma.