The somatic mutation landscape of ccRCC has been well characterized, and VHL, PBRM1, SETD2, and BAP1 are the most commonly mutated genes.9,42 The mutation profile observed in our patients was well in line with previous findings, and VHL and PBRM1 were among the most commonly mutated genes. This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.