Studies measuring CSF levels of amyloid-beta (Ab1-42), total Tau (t-Tau) and phosphorylated Tau (p-Tau) in LRRK2-PD, and asymptomatic LRRK2 carriers and IPD patients showed no differences between groups [105, 106] Mov Disord 2016, although their correlation with cognitive decline in this form of genetic PD has been not investigated yet. This evidence concerns the gene MAPT and Parkinson disease.