The Akt/c-Met-induced HCC mice were launched by Chenxin's Lab that refers to Sleeping Beauty (SB) transposon-mediated high-pressure caudal vein hydrodynamic plasmid transfection [32], which has become one of the effective methods for the establishment of mouse liver cancer models because of the short modeling cycle, uniform tumor formation, and simple operation [32]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.