In order to test this hypothesis, CCK-8 assays were used to verify that overexpression of ADAM23 markedly inhibited the proliferation of ESCC cells while silencing ADAM23 significantly promoted the proliferation of ESCC cells (p < 0.05) (as shown in Figure 4(d) and Supplementary Figure 3D). Here, ADAM23 is linked to esophageal squamous cell carcinoma.