L1CAM and neoplasm: Previous studies have revealed that L1CAM is involved in the malignant phenotype of tumors through various signaling pathways, the more classic being the Wnt/β-catenin/TCF pathway that promotes tumor metastasis, but also by activating the Ras/Raf/Mek/Erk signaling pathway to promote epithelial-mesenchymal transition [44, 45].