VOPP1 and rheumatoid arthritis: Thus, the cross-talk genes and pyroptosis-related genes in the module were extracted; thereby, three genes, i.e., TIMP1, LGALS1, and GPX4 (pyroptosis), were in the blue module of PD network, while two genes, i.e., VOPP1 and AIM2 (pyroptosis), were in the blue module of RA.