GPX4 and rheumatoid arthritis: Figure 9(d) shows that all these five genes were significantly upregulated in case samples of PD compared with control healthy samples.  Figure 9(e) shows that among five important genes, three genes (AIM2, TIMP1, and VOPP1) were significantly upregulated in case samples of RA, while the other two genes (GPX4 and LGALS1) were not found to be dysregulated in RA.