ACLY and familial pancreatic carcinoma: For instance, the main enzymes participating in de novo lipogenesis include fatty acid synthase (FASN), ATP citrate lyase (ACLY) and Acetyl-CoA Carboxylase (ACC), and studies have shown that the altered expression levels of these enzymes are closely related to increased migration and invasion of cancer cells in various cancers, such as pancreatic cancer, breast cancer (BC), HCC and so on 23-26.