Recently a study has reported that chronic acidosis in TME induces LDs formation in cancer cells and leads to more metastasis, with CD36 and diacylglycerol acyltransferase (DGAT) as key players to mediate LD biogenesis via the uptake of exogeneous FAs and triglyceride synthesis in a TGFβ2-dependent way 19. The gene discussed is CD36; the disease is cancer.