CuET inhibits ALDH1A3, an important isoform of the aldehyde metabolic enzyme system ALDH family, by selectively enhancing expressions of miR-16-5p and miR-15b-5p and then inhibits the ubiquitination of PKM2, so as to alleviate the glycolysis of CRC cells. This evidence concerns the gene LDHA and colorectal carcinoma.