PTPRO and colorectal cancer: Although we observed higher expression of PTPRO in colorectal cancer compared with normal samples (Figure 1B), two cohorts (GSE17537 and GSE17537) indicated that the high expression of PTPRO seems to be associated with better prognosis (OS HR = 0.57, 95% CI = 0.36 to 0.91, Cox P = 0.02; DFS HR = 0.56, 95% CI=0.34 to 0.93, Cox P = 0.03).