Notably, PTPRO expression was positively related to the levels of CD8+ T cell infiltration (r = 0.668, P = 1.78e-23), neutrophils (r = 0.73, P = 1.00e-29), macrophages (r = 0.519, P = 3.45e-13) and dendritic cells (r = 0.817, P = 2.44e-42) in pancreatic cancers. Here, CD8A is linked to familial pancreatic carcinoma.