Our study suggested that the invasion and migration abilities were both inhibited after downregulation of CD147 protein and recovered after the addition of human recombinant HE4 active protein, indicating that CD147 and HE4 could interacted with each other to form a protein complex, and HE4 could promote invasion and metastasis of ovarian cancer by regulating the expression of CD147. This evidence concerns the gene BSG and ovarian cancer.