WFDC2 and cancer: We further divided malignant tumors into low (-/+) and high (++/+++) HE4 expression group, the results showed that the high positive expression rates of HE4 in malignant group, borderline group, benign group and normal group were 67.7% (65/96), 36.4% (4/11), 28.6% (4/14) and 16.7% (2/12), respectively.