Degradation of extracellular matrix is the premise of tumor cell invasion and metastasis, as an extracellular matrix metalloproteinase inducer, CD147 is a cancer-specific biomarker, which can not only mediate intercellular adhesion, but also induce production of extracellular MMPs, playing a key role in promoting tumor invasion and metastasis 23-24. Here, BSG is linked to cancer.