We further constructed the stable low expression CD147 ovarian cancer cells OV-CD147-L and ES-CD147-L and their negative control groups OV-NC and ES-NC by lentivirus transfection, the results showed that the expression of HE4 decreased and the expression of AXNA2 protein did not change significantly after the expression of CD147 was inhibited in OV-CD147-L and ES-CD147-L cells by Western blot (Figure 7A and Supplementary figure 3A). Here, WFDC2 is linked to ovarian carcinoma.