According to the results above, silencing DRP1 and MFN2 by siRNA provides a reliable means to manipulate mitochondrial dynamics in SKOV3 and SKOV3/DDP cells, and it is also important for exploring the role of mitochondrial dynamics mediated by DRP1 and MFN2 in the development of DDP chemoresistance in ovarian cancer. The gene discussed is MFN2; the disease is ovarian cancer.