IGFBP3 and posterior cortical atrophy: We first compared the expression levels of IGFBP3 in PCa and found that the expression of IGFBP3 was significantly upregulated in CRPC patients by the IHC assay, which is consistent with the finding that IGFBP3 may be upregulated in the CRPC owing to the LOX deficiency (Fig. 4A).