In esophageal squamous cell carcinoma, YAP1 has been shown to upregulate Gli1 30, which is in accordance with our previous study in gastric cancer 30, representing that YAP1 enhances cell migration and proliferation via regulating Gli1 expression through the AKT/mTOR signaling pathway. Here, AKT1 is linked to esophageal squamous cell carcinoma.