Furthermore, LATS1 protein expression levels in CRC tumor tissues with larger tumor sizes (≥5 cm), deeper invasion (T3-4), positive lymph node metastasis (LNM), or advanced tumor-node-metastasis (TNM) stage (III-IV) were lower significantly as compared to control groups (Figure 1D-G). The gene discussed is LATS1; the disease is colorectal carcinoma.