Given the facts that LATS1 is a critical regulator of YAP1 5 and YAP1 can upregulate Gli1 expression in esophageal squamous cell carcinoma 30 and gastric cancer 31, we speculated that YAP1 might be implicated in LATS1-mediated Gli1 suppression. This evidence concerns the gene GLI1 and esophageal squamous cell carcinoma.