For the regional lymph node metastasis status (presence - N1, absence - N0), ACVR1B and PIK3CG showed similarly low mutation frequencies in tumors with regional lymph node metastasis for both of Korean (ACVR1B - N1: 1.3%, N0: 9.7%, p = 0.022; PIK3CG - N1: 0%, N0: 7.5%, p = 0.016) and Caucasian (ACVR1B - N1: 1.1%, N0: 8.6%, p = 0.025; PIK3CG - N1: 2.2%, N0: 12.1%, p = 0.008). Here, PIK3CG is linked to metastatic malignant neoplasm in the lymph nodes.