IGFBP7 and cancer: For instance, “plasminographic activator 1 (PAI1), interleukin 6 (IL-6), interleukin 8 (IL-8), insulin-like growth factor binding protein7,” cell cycle arrests, carcinogenesis (IGFBP7), and growth factor-β (TGF-β) transformation can lead to cancer cell apoptosis [43].