For example, several microRNAs, like microRNA-26a, microRNA-137, and microRNA-148, can serve as tumor suppressors by targeting MITF, a master regulatory gene, in melanoma [8–10], while some other microRNAs, like microRNA-10b, microRNA-17, and microRNA-19, are considered as tumor-promoting factors by targeting ITCH, ETV1, and PITX1, respectively, in melanoma [11–13]. The gene discussed is PITX1; the disease is melanoma.