During EMT, epithelial cells lose epithelial markers, such as E-cadherin, which is the main molecule of stable epithelial adherens junctions, so that the invasion-metastasis cascade is promoted, resulting in the exit of tumor cells from the primary site, invasion to adjacent organs, intravasation, and distant metastasis via the blood or lymphatic system. The gene discussed is CDH1; the disease is neoplasm.