According to the degree of topological analysis, it showed that APP, AKT1, VEGFA, ALB, PIK3CA, LPAR1, LPAR3, SRC, EGFR, STAT3, PIK3R1, CASP3, MAPK1, and MTOR play important roles in the therapeutic effect of PNS in AD. The gene discussed is PIK3CA; the disease is Alzheimer disease.