According to the degree of topological analysis, it showed that APP, AKT1, VEGFA, ALB, PIK3CA, LPAR1, LPAR3, SRC, EGFR, STAT3, PIK3R1, CASP3, MAPK1, and MTOR play important roles in the therapeutic effect of PNS in AD. This evidence concerns the gene PIK3R1 and Alzheimer disease.