TNF and brain infarction: Chen (Chinese name: Sanqi), as a typical TCM for promoting blood circulation and removing blood stasis, studies found that Panax notoginseng saponins can directly downregulate the overexpression of proinflammatory factors like interleukin-1β and tumor necrosis factor-α, and at the same time upregulate the expression of anti-inflammatory factors like interleukin-10 in the core area of cerebral infarction, thereby preventing permanent nerve damage in rats after MCAO.