SOX9 and neoplasm: MYC can contribute to oncogenesis and immune evasion through various mechanisms, including the promotion of autonomous cell growth and proliferation, modulation of tumor–stroma interactions, and regulation of the host immune system (Dang, 2012; Paglia et al., 2020; Dhanasekaran et al., 2021; Lourenco et al., 2021), while the mechanism of action that underlies the function of MYEOV in cancer development and metastasis may enhance SOX9 transcriptional activity (Lawlor et al., 2010; Fang et al., 2019; Liang et al., 2020).