COPZ1 and cancer: Shtutman et al. (2011) explained the operational mechanism of COPZ1 (cg05147638 located) in the tumor cell: the function-based genomic screening identified COPZ1 gene is essential in different tumor cell types instead of normal cells. Gene COPZ1 methylation is harmful. This conclusion approves our results: β^= 0.4918. As for CpG site cg24720672, we find some researches about leukemia—a kind of cancer, and we infer it has the similar mechanism in tumor tissue as lung cancer (Nair, 2016; Zhang et al., 2018; Jiang et al., 2020).