According to the data, numerous genes (such as H2AFX, CDKN2A, TTF2, IKBKE, and UBE2I) were markedly upregulated in many cancer types, while some genes (such as ARRB1, LMO3, KHDRBS2, CIRBP, and RALYL) were remarkably downregulated in multiple cancer types (Figure 9B). Here, H2AX is linked to cancer.