METTL3 and neoplasm: However, the m6A regulators exerted their functions in tumor development and might also collaborate with each other or other factors, and accumulating lines of evidence had indicated that m6A regulators might play a dual role as tumor promoters or tumor suppressors in variously different cancer types, implying that the levels or functions of m6A RNA methylation were determined by the collaboration of m6A regulators in certain conditions (Roundtree et al., 2017; Panneerdoss et al., 2018).