The CNV pie plots revealed that several readers (YTHDF1, YTHDF3, IGF2BP1, IGF2BP2, IGF2BP3, and HNRNPA2B1) exhibited very high percentages of heterozygous CNVs, particularly amplification (Hete Amp) in multiple cancer types, while genes like RBM15B, ALKBH5, METTL14, ZC3H13, and WTAP had high percentages of heterozygous CNVs with depletion (Hete Del) (Figure 2B). The gene discussed is IGF2BP3; the disease is cancer.