Furthermore, multivariate analysis confirmed that tumor lymph-node metastasis [p = 0.0025, HR = 2.547, 95% CI (1.3891–4.669)] and exosomal LINC00917 expression level [p = 0.0038, HR = 2.115, 95% CI (1.2732–3.514)] may act as independent factors to predict NSCLC patients’ OS. This evidence concerns the gene LINC00917 and non-small cell lung carcinoma.