BAX and rheumatoid arthritis: Imperatorin (IPT) has been demonstrated to reduce the survival of FLS influenced by IL-1β; promote the apoptosis of FLS by increasing the release of mitochondrial cytochrome c, the ratio of Bax/Bcl-2, and other mitochondrial pathways in RA; and alleviates collagen-induced arthritis by reducing the expression of MMP1/3 (32).