Furthermore, tangeretin and 5-hydroxy-6,7,8,3’,4’-pentamethoxyflavone have also been shown to inhibit autophagy by regulating ROS levels in synovial cells and AKT/mTOR signaling, thereby inhibiting the pathological changes associated with bovine type II collagen-induced arthritis in animals (134). The gene discussed is AKT1; the disease is arthritic joint disease.