For instance, induction of activation-induced cell death (AICD), by the CD44 mediated FasL expression on the surface of T cells through the activation of a tyrosine kinase, IP3 receptor-dependent Ca2+ mobilization, and actin cytoskeletal rearrangements; eliminates self-reactive T cells thereby, suppressing RA (7). This evidence concerns the gene CD44 and rheumatoid arthritis.