In order to study the impact of pregnancy on the IFN-γ production upon M. tuberculosis antigen stimulation, the plasma IFN-γ concentrations in response to TB1 and TB2 were measured with the QFT-P assay in pregnant and non-pregnant women within the active clinical TB subgroup: pATB vs. ATB; the non-confirmed-TB pregnant women with positive QFT-P (pLTBI+) vs. the healthy non-pregnant women with positive QFT-P (LTBI+); and the non confirmed-TB pregnant women with negative QFT-P (pLTBI-) vs. healthy non-pregnant women with negative QFT-P (LTBI-) (Figure 1). This evidence concerns the gene REEP5 and tuberculosis.