This hypothesis is in line with an earlier study by Shankar and co-workers (36) who investigated the biological relevance of PRF- and FasL-mediated cytolytic pathways of CD8+ CTL for cancer immunotherapy in a murine renal cell carcinoma model with tumor cells expressing influenza viral hemagglutinin (Renca-HA) as a defined surrogate antigen. This evidence concerns the gene CD8A and neoplasm.