Since the putative role of exosomes and their cargo proteins in the regulation of T cell-mediated immune responses and autoimmune diseases has been recently reviewed by Anel and co-workers (67) and Del Vecchio and colleagues comprehensively reviewed the role of extracellular vesicles in the interactions between NK cells and CD8+ CTL and tumor cells (68), we will focus on the potential relationship between intra- and extracellular vesicles in the following. Here, CD8A is linked to neoplasm.