found that attenuated Salmonella typhimurium (ST) delivering an shRNA plasmid targeting IDO1 can reduce intratumoral IDO1 levels more effectively than epacadostat (121), while locked nucleic acid (LNA)-modified antisense oligonucleotides (ASOs) could inhibit IDO1 expression in cancer cells, exhibiting longer exposure times and more engaged targets than epacadostat (122). The gene discussed is IDO1; the disease is cancer.