NFKB1 and infection: Nevertheless, three main reasons support the fact that resistant chickens were infected; 1) the high viral dose used for the experimental infections (59); 2) the fact that within the 39 DEGs obtained in resistant chickens in contrast to control chickens, we found IFN-I regulated genes (Interferome v2.1 database) and genes related to defense response (Gene Ontology analysis); and 3) some DEGs downregulated in resistant chickens but upregulated in the susceptible ones were related to innate immune pathways such as Nf-kB and MAPK signaling.