It is now necessary to clarify: 1) TREM2 is a PD susceptibility factor in which populations; 2) In what context does TREM2 function, whether it is affected by time, how does TREM2 function, which pathologies of PD are affected by its function, changes in expression, and signal transduction, and whether it affects multiple PD pathologies simultaneously; 3) ADAM10/17 is an abscission enzyme in TREM2 expression, and its inhibitor might enhance TREM2 expression but has multi-target effects. Here, TREM2 is linked to Parkinson disease.