Another study identified 1873 lncRNAs derived from the plasma of SLE patients through gene ontology analysis, with 221 upregulated and 1652 downregulated lncRNAs (lg|FC| ≥ 2.0 and P ≤ 0.05), of which Yippee-like-4 (YPEL4) was related to the receptor immunoglobulin G (FcγR) pathway (69). This evidence concerns the gene YPEL4 and systemic lupus erythematosus.