The rs145204276 ID/DD genotypes in the promoter region of the LncRNA-GAS5 gene may have a protective effect against SLE by up-regulating LncRNA-GAS5 expression and its targets miR-21 and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) (48). The gene discussed is GAS5; the disease is systemic lupus erythematosus.