Twenty KEGG pathways related to the ICPBS, including the MAPK signaling pathway, natural killer cell-mediated cytotoxicity, the P53 signaling pathway, T-cell receptor signaling pathway, B-cell receptor signaling pathway, pathway in cancer, primary immunodeficiency, and intestinal immune network for IgA production (Figure S11), were identified by GSEA. This evidence concerns the gene TP53 and cancer.