RA requires the combined effects of different signaling pathways, such as receptor activator of nuclear factor kappa B ligand (RANKL)/receptor activator of nuclear factor kappa B (RANK)/osteoprotegerin (OPG) and IL-6/glycoprotein 130 (gp130)/janus kinase (JAK)/signal transducer and activator of transcription (STAT). This evidence concerns the gene TNFSF11 and rheumatoid arthritis.