IL6 and rheumatoid arthritis: An analysis of the -174 (rs1800795) -GC IL-6 gene promoter polymorphism in RA patients revealed that genotype -GG may be associated with a poorer response to methotrexate when compared to genotypes -GC and -CC (54), which was in disagreement with another study identifying no association between -GG genotype or G allele and risk of therapeutic failure using different measures for defining response to therapy (55) (Table 1).