IFNG and neoplasm: Julien Cherfils-Vicini (27) and Tobias Eggert (28) also confirmed that in melanoma and HCC, recruitment of MDSCs in tumor site enhanced the inhibition of NK cell functionality, manifested in significantly decreased NK cell degranulation and IFN-γ production, and strongly affected NK cell cytotoxicity, ultimately resulting in tumor progression and metastasis.