MDSCs triggered expression of miRNA101, a conserved non-coding RNA that fine-tunes gene expression, regulates cell differentiation and cell-fate determination, in ovarian carcinoma cells, which subsequently repressed the corepressor gene C-terminal binding protein-2 (CtBP2) that directly targeted stem cell core genes, thereby resulting in enhancing CSC gene expression, sphere formation, and increasing metastatic and tumorigenic potential (69). This evidence concerns the gene CTBP2 and ovarian carcinoma.