CD8+ T-cell activation in response to PD-1 blockade induced a PD-L1/NLRP3 inflammasome signaling cascade that ultimately led to the recruitment of CXCR2+PMN-MDSCs into tumor tissues through HSP70/TLR4/Wnt5a/CXCL5 signaling axis, thereby dampening the resulting antitumor immune response. This evidence concerns the gene CD8A and neoplasm.