CXCL8 and Oral leukoplakia: IL-8 is also produced by gingival epithelial cells in response to oral microbiota in vitro (92) and by nicotine (93), while a recent review has referenced data showing upregulation of IL-8 in oral diseases such as Oral Lichen Planus and periimplantitis with contradictory results in some studies of oral Leukoplakia (75).