For instance, IL-8 and IL-10 are increased in both BD saliva (ΔIL-8 = 178.2pg/ml, ΔIL-10 = 20.35pg/ml) and serum (ΔIL-8 = 17.6 pg/ml, ΔIL-10 = 11.9 pg/ml) whereas in RAS patients, IL-8 and IL-10 levels are higher only in saliva (ΔIL-8 = 575 pg/ml, ΔIL-10 = 40.3pg/ml) (Supplementary Table S1). This evidence concerns the gene CXCL8 and Behcet disease.