An increase in IL-8 mRNA has been shown to be directly associated with BD serum-treated macrophages from HC in vitro (83) and although there was a diverse source of IL-8 from various cells (including neutrophils, monocytes, macrophages, endothelial and epithelial cells), lymphocytes were considered to be the major contributors (84). This evidence concerns the gene CXCL8 and Behcet disease.