Also in a meta-analysis, IL-8, IL-1β, TNF-α, IL-6, and IL-1α were found to be increased in oral cancer compared to HC and leukoplakia and were suggested as cancer biomarkers (137) In our study, the significant differences between HC and BD-MQ is an important finding to be able to differentiate the levels of cytokines present in “normal” saliva content and orally asymptomatic BD patients saliva. This evidence concerns the gene IL1B and lip and oral cavity carcinoma.