MAPT and Alzheimer disease: Most importantly, alterations in the genetic transcripts for AZIN2, which influence the deposition of tau (a protein that accumulates in dementia-causing diseases) and production of putrescine, spermidine, and spermine, have recently been uncovered in humans with Alzheimer’s disease (Sandusky-Beltran et al., 2021), lending to the development of the idea that polyamines are integral to the accumulation of toxic protein in the development and progression of tauopathies and similar diseases (Sandusky-Beltran et al., 2021).