We hypothesized that IFNγ stimulation of MCC cell lines would lead to transcriptomic alterations that elucidate the ambiguous pro- and anti-tumoral activity of this cytokine and hence examined the effect of IFNγ on the transcriptomes of three MCPyV-positive cell lines (WaGa, MKL-1, and MKL-2). This evidence concerns the gene IFNG and Merkel cell skin cancer.