Engineered attenuated Salmonella carrying expression plasmids of endostatin linked with RGD peptides or anti-PSMA scFv (ST/RGD4C-ES, RGD10-ES, and PSMA-ES) showed significantly stronger suppressive effects on tumor growth compared to ST/3342 (p < 0.05 or 0.01, data not shown). Here, COL18A1 is linked to neoplasm.