COL18A1 and neoplasm: Besides, to increase the specificity of endostatin’s anti-angiogenic anti-tumor activity, endostatin was linked to short RGD (arginine-glycine-aspartate) peptides or anti-prostate specific membrane antigen (PSMA) single-chain variable fragment (scFv), respectively, both of which could bind to overexpressed surface proteins of proliferating endothelial cells with high affinity and selectivity, i.e., the αvβ3 integrin and PSMA (Liu et al., 1997; Weis and Cheresh, 2011; Danhier et al., 2012; Afshar-Oromieh et al., 2016).