Therefore, we attempted to use the optimized Salmonella vector to deliver the apoptosis inducer TRAIL, of which the anti-tumor efficacy was also tested in this study (Supplementary Figures S4A,B), in addition to anti-angiogenic endostatin and expected that both cancer cells and proliferating endothelial cells of tumor vasculature could be targeted. The gene discussed is TNFSF10; the disease is cancer.