Neonatal gut microbiota affect the susceptibility of allergic asthma in children, possibly affecting CD4 + T cell populations and function through changes in the gut microenvironment. Labeled NGM3, the highest risk group, exhibit higher relative abundance of particular fungi (for example, Rhodotorula and Candida), lower relative abundance of certain bacteria (Faecalibacterium, Akkermansia and Bifidobacterium), and a unique fecal metabolome rich in pro-inflammatory metabolites. This evidence concerns the gene CD4 and allergic asthma.