MTOR and Infertility: For instance, Sertoli cell-specific deletion of mTOR led to infertility in mice, which associated with a surge in p-rpS6 expression, loss of Sertoli cell polarity, increased in germ cell apoptosis and extensive germ cell exfoliation, but also gap junction impairment due to mislocalization of connexin 43 (Cx43) (98).