For instance, Sertoli cell-specific deletion of mTOR led to infertility in mice, which associated with a surge in p-rpS6 expression, loss of Sertoli cell polarity, increased in germ cell apoptosis and extensive germ cell exfoliation, but also gap junction impairment due to mislocalization of connexin 43 (Cx43) (98). This evidence concerns the gene GJA1 and Infertility.