Since PSMA uptake mechanism is I – Na symporter independent, its application in patients with this type of cancer, may have several benefits and/or advantages over the actual SOC imaging modality, being the first of them not requiring levothyroxine suppression, as well as identifying precociously, lesions with a more aggressive potential that could be going through radioiodine refractoriness. This evidence concerns the gene FOLH1 and cancer.