In addition, c.2268dupT (p.E757fs or p.E757*), a non-sense mutation in the exon 13 of the TPO gene, is reported as a hotspot mutation in Taiwanese and Malaysian–Chinese patients and the most common genetic cause of dyshormonogenetic CH with evidence of cofounder effect (10, 30, 32). Here, TPO is linked to cyclic hematopoiesis.