KDR and epilepsy: Therefore, based on our previous studies, we performed the present study to investigate the critical role of VEGF and VEGFR-2 inhibitor SU5416 expression regulation and the time-dependent effect of the VEGF on neurogenesis and microvascular remodeling in the immature brain after SE to explore the role of VEGF in the development of epilepsy and to provide new ideas for the prevention and treatment of epilepsy.