SRS emergence is a key indicator of the occurrence and development of epilepsy, and our data showed that downregulation of VEGF expression in the latent phase after SE could effectively reduce the severity of epileptic discharges during SRS by shortening the duration of each seizure and reducing the frequency and number of seizures, suggesting that the key regulatory period of epileptogenesis is the latent phase. Here, VEGFA is linked to epilepsy.