SIRT1 and stroke disorder: In fact, in a pre-clinical study, the use of resveratrol (RESV), an exercise mimetic drug, during the early acute phase of stroke, limited muscular atrophy, through the activation of SIRT1, and normalized the hypertrophy of slow-twitch muscle fibers (I, IIa), suggesting that RESV may improve oxidative metabolism in stroke-affected muscles (25).