As expected, myelin proteins (log2 fold change, MAG = −1.93, ERMN = −2.45, BCAS1 = −1.94, OMG = −1.51, VCAN = −2.16) were found to be downregulated in demyelinated WMLs of progressive MS brains (Supplementary File 1). This evidence concerns the gene VCAN and myeloid sarcoma.