However, it is possible that the levels of these and other cytokines/chemokines, such as IL-6 and TNF-α, may be dysregulated in the brain or blood of older-adults with depression and anxiety; since other cognitive therapies such as CBT, have shown to reduce symptoms of depression and the levels of IL-6 and TNF-α (55). The gene discussed is TNF; the disease is major depressive disorder.