Since IL1β strongly correlates with BMI, insulin resistance, and chronic inflammation (61, 62) and is implicated in various cardiometabolic conditions, such as obesity (63), diabetes (35, 36), and atherosclerosis (64, 65), these factors should be taken into consideration when proinflammatory cytokines are studied. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.