GPX1 and nuclear cataract: GPX-1 is involved in the glutathione redox cycle and GPX-1 knockout in mice lead to the formation of age dependent nuclear cataracts and a reduced number of functional Cx46 and Cx50 channels, implying that channel oxidation lowered the gap junctional coupling conductance of MF and DF cells (Reddy et al., 2001; Wang et al., 2009).