AGT and Hypertension: For example, impaired glucose tolerance and insulin resistance are caused by conditional knockout of Lrrc8a expressing in adipocytes (Zhang et al., 2017), pancreatic β cells (Kang et al., 2018), and skeletal muscle cells (Kumar et al., 2020); male infertility by germ cell-specific Lrrc8a disruption (Lück et al., 2018); angiotensin-II-stimulated hypertension by endothelial-targeted Lrrc8a knockout (Alghanem et al., 2021); and brain hyperexcitability coupled to astrogliosis by brain-specific Lrrc8a disruption (Wilson et al., 2021).