Studies with Slco2a1 knockout mice suggested that SLCO2A1 is involved in promotion of colon cancer (Nakanishi et al., 2017), bleomycin-induced fibrosis (Nakanishi et al., 2015), and LPS-induced febrile responses (Nakamura et al., 2018). This evidence concerns the gene SLCO2A1 and malignant colon neoplasm.