PACC1 and cancer: Indeed, a number of human disease-associated mutations in genes encoding LRRC8A (see Review: Vaeth and Feske, 2018) and SLCO2A1 (see Reviews: Madruga Dias et al., 2014; Stumpff, 2018; Nakanishi et al., 2021) as well as by association of cancer progression with TMEM206 expression (Zhao J. et al., 2019; Zhang et al., 2020) have been reported.