It is also noted that downregulation of VSOR/VRAC activity (Lee et al., 2007) and LRRC8A expression (Planells-Cases et al., 2015; Sørensen et al., 2016a,b; Thorsteinsdottir et al., 2016) is associated with acquisition of cisplatin resistance by cancer cells. This evidence concerns the gene LRRC8A and cancer.