On the other hand, ischemia-induced brain infarct was found to be partially protected not only by astrocyte-specific Lrrc8a knockout presumably by suppressing excitotoxicity (Yang et al., 2019b) but also by neuron-targeted Lrrc8a disruption presumably through inhibition of apoptosis induction (Zhou et al., 2020). This evidence concerns the gene LRRC8A and brain infarction.