Moreover, in humans, common SNPs in the promotor of CD36 cause protein deficiency and have been associated with high levels of FAs and LDL in serum, a phenotype recapitulated in Cd36−/− mice (Miyaoka et al., 2001; Ma et al., 2004; Goudriaan et al., 2005; Yamashita et al., 2007; Love-Gregory et al., 2011). Here, CD36 is linked to protein S deficiency.