In cardiomyocytes, Hong et al., 2014 have shown that one of four cBIN1 isoforms in mouse adult cardiomyocyte (BIN1+13+17) was involved in cardiomyopathy and arrhythmia by regulating ion flux and TT morphology (Hong et al., 2014). The gene discussed is BIN1; the disease is cardiac arrhythmia.