BIN1 and hydrops fetalis: Although cardiac TT remodeling and associated dysfunction of Ca2+ release have been extensively reported in HF (Balijepalli et al., 2003; Louch et al., 2004, 2012; Song et al., 2006), the processes underlying the formation and maintenance of TTs in general are not known, although we do know that BIN1 seems to be a critical component of TT assembly.